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Early Diffusion of Gene Expression Profiling in Breast Cancer Patients Associated with Areas of High Income Inequality (Health Affairs)

Publication Topics

Access to Health Care; Women; Low-Income; Cancer

Publication Type

Journal Article

Publication Date


Author 1

<a onclick="OpenPopUpPage('{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=243&RootFolder=*', RefreshPage); return false;" href="{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=243&RootFolder=*">Ninez A. Ponce, PhD, MPP</a>

Author 2

<a onclick="OpenPopUpPage('{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1148&RootFolder=*', RefreshPage); return false;" href="{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1148&RootFolder=*">Michelle Ko MD, PhD</a>

Author 3

<a onclick="OpenPopUpPage('{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1195&RootFolder=*', RefreshPage); return false;" href="{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1195&RootFolder=*">Su-Ying Liang</a>

Author 4

<a onclick="OpenPopUpPage('{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1196&RootFolder=*', RefreshPage); return false;" href="{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1196&RootFolder=*">Joanne Armstrong</a>

Author 5

<a onclick="OpenPopUpPage('{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1197&RootFolder=*', RefreshPage); return false;" href="{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1197&RootFolder=*">Michele Toscano</a>

Author 6

<a onclick="OpenPopUpPage('{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1198&RootFolder=*', RefreshPage); return false;" href="{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1198&RootFolder=*">Catherine Chanfreau-Coffinier, PhD</a>

Author 7

<a onclick="OpenPopUpPage('{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1199&RootFolder=*', RefreshPage); return false;" href="{7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1199&RootFolder=*">Jennifer S. Haas</a>

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With the Affordable Care Act reducing coverage disparities, social factors could prominently determine where and for whom innovations first diffuse in health care markets. Gene expression profiling is a potentially cost-effective innovation that guides chemotherapy decisions in early-stage breast cancer, but adoption has been uneven across the United States.

Using a sample of commercially insured women, the authors evaluated whether income inequality in metropolitan areas was associated with receipt of gene expression profiling during its initial diffusion in 2006–07.

In areas with high income inequality, gene expression profiling receipt was higher than elsewhere, but it was associated with a 10.6-percentage-point gap between high-income and low-income women. In areas with low rates of income inequality, gene expression profiling receipt was lower, with no significant differences by income. Even among insured women, income inequality may indirectly shape diffusion of gene expression profiling, with benefits accruing to the highest-income patients in the most unequal places. Policies reducing gene expression profiling disparities should address low-inequality areas and, in unequal places, practice settings serving low-income patients.


Article 1

Journal Article: Early Diffusion of Gene Expression Profiling in Breast Cancer Patients Associated with Areas of High Income Inequality

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Press Release

Related Link 1

National Institutes of Health

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Harvard Catalyst, the Harvard Clinical and Translational Science Center

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The TRANSPERS Center for Translational and Policy Research on Personalized Medicine

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Version: 4.0
Created at 4/6/2015 9:20 AM by i:0#.f|uclachissqlmembershipprovider|celeste
Last modified at 4/6/2015 2:32 PM by i:0#.f|uclachissqlmembershipprovider|gwendolyn