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Building a Population Representative Pediatric Biobank: Lessons Learned from the Greater Cincinnati Childhood Cohort (PLoS One)

Publication Topics

California Health Interview Survey; African-American; Hispanic/Latino; Local-level/Community Population

Publication Type

CHIS Journal Article

Publication Date


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Summary: Biobanks can accelerate research by providing researchers with samples and data. However, hospital-based recruitment as a source for controls may create bias as who comes to the hospital may be different from the broader population.

In an effort to broadly improve the quality of research studies and reduce costs and challenges associated with recruitment and sample collection, a group of diverse researchers at Cincinnati Children's Hospital Medical Center led an institution-supported initiative to create a population representative pediatric “Greater Cincinnati Childhood Cohort (GCC).” Participants completed a detailed survey, underwent a brief physician-led physical exam, and provided blood, urine, and hair samples. DNA underwent high-throughput genotyping.

Findings: In total, 1,020 children ages 3–18 years living in the seven-county Greater Cincinnati Metropolitan region were recruited. Racial composition of the cohort was 84% non-Hispanic white, 15% non-Hispanic black, and 2% other race or Hispanic. Participants exhibited marked demographic and disease burden differences by race. Overall, the cohort was broadly used resulting in publications, grants and patents; yet, it did not meet the needs of all potential researchers.

Learning from both the strengths and weaknesses, authors propose leveraging a community-based participatory research framework for future broad use biobanking efforts.

This study refers to California Health Interview Survey (CHIS) data. 


Article 1

CHIS Journal Article: Building a Population Representative Pediatric Biobank: Lessons Learned from the Greater Cincinnati Childhood Cohort

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Press Release

Related Link 1

California Health Interview Survey (CHIS)

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Version: 4.0
Created at 5/18/2021 10:11 AM by i:0#.f|uclachissqlmembershipprovider|celeste
Last modified at 6/14/2021 3:32 PM by i:0#.f|uclachissqlmembershipprovider|venetia